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Potentially, modification of Skp1 Pro143 could modify the pucker of its pyrrolidine ring and/or trans: cis isomerization of the Thr Pro143 peptide bond that could initiate the global conformational reorganization that we propose results in improved Fbs1 binding.
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One potentially unstable modification is highlighted in Figure 4.
Potentially cultural modification accounted for only a small portion of the cortical damage to the bones.
They usually do not create a long-lasting and potentially irreversible modification (phase 3).
This potentially beneficial modification is not employed as often as C-terminal amidation alone.
Our assay was conducted in IVT lysate and the size increase of the ISG15VS adduct could potentially reflect modification of USP14 by additional factors.
Single-stranded DNA regions are intrinsically more prone to breakage and potentially mutagenic modification than when in the double-stranded form.
Another potentially important modification of data is the withholding of information which could reflect adversely on the hospitals, such as consistency of diagnosis, bedsores and iatrogenic infection.
The other potentially reversible modification of ISPs is phosphorylation through the action of protein kinases and phosphatases, although the relevant enzymes have not yet been identified.
Knowledge about the potential for changing individual risk of developing dementias is important as the transmission of such information could potentially prompt modification of lifestyle factors that contribute to the development or progression of dementia.
If potential adapters only see/hear about modified versions of SCALE-UP, the likelihood of (potentially detrimental) modifications will increase.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com