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In addition, this genome-level approach has the potential to reduce investigator bias, and thus increase discovery capability, in as much as all genes are potentially interrogated, rather than a specific set of genes chosen by the investigator based on a priori and potentially biased assumptions.
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In summary, probes located nearer to the 3′-end of the interrogated transcripts potentially shine brighter than more distant probes due to the 3′-enrichment of probe coverage giving rise to expected 'true' intensity ratios r5′/3′ < 1.
It has to be emphasized that in over 40%% of the pop-diff probes with a SNP in the targeted dinucleotide, other potentially confounding features were present; however, for most of them the presence of a SNP in the interrogated CpG appeared to exert the strongest effect upon methylation readouts.
In total, we analyzed 152 probes in 4 different probe mixes (see Methods) that interrogated 93 of the 111 CNV regions, including 60 CNVs already described in the literature and 33 potentially novel CNVs.
All interrogated.
He is tried, convicted, and interrogated.
The eight were interrogated and released.
Then having her interrogated by a child.
"Stephanie interrogated numerous aspects of the figures in her analysis.
We had watched him being tortured and interrogated on TV.
He had been interrogated and tortured seven or eight times.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com