An interesting distinction to keep in mind when considering phenotypes resulting from circadian gene disruption is whether the phenotype could be due to loss of rhythmicity of gene expression, versus due to the potentially disruption-specific effects on gene expression level.
Charlie Kronick, senior climate advisor for Greenpeace said: "The potential disruption to the global economy from over dependence on fossil fuels – not to mention the potentially catastrophic disruption to the global environment from climate change - means that every investor and legislator should take the carbon bubble seriously – and act upon it.
For the commission, the Bush plan is a potentially serious disruption of its mission.
Alice interprets this development as a potentially devastating disruption of all her dreams -- of staying at Midwood, of completing her Intel project, of getting into a top-drawer East Coast college.
Potentially genetic disruption of the P-gp encoding genes may induce upregulation of other transporters (i.e., multidrug resistance protein 1, and breast cancer resistant protein (Bcrp 1), while chemical inhibition of P-gp function might also inhibit other transporters, such as Bcrp1, in the case of tariquidar [11].
One of the bros decided to go skinny-dipping in that pool, "causing potentially significant disruption to their habitat" and damaging scientific equipment used to monitor the site.
Large, intermingled assemblages of horses from diverse sources provide an opportune environment for viral shedding and transmission, exacerbated by potentially stressful disruption of established social groups [ 9, 10, 17].
Individual patient randomisation would not be feasible as the POC tests would then be used for some patients but not others within the same health service, potentially causing disruption and confusion for health service staff and patients.
Potentially, the disruption of the basement membrane due to the injury or attrition of the myofibers, differentiation of satellite cells along myogenic lineage, and/or extracellular matrix - based activation of FGF-2 for binding to its receptors might be required for the induction of FGF-2 signaling in the muscle stem cells responding to tissue damage.
The limit must be raised so the government can borrow what it needs to meet its obligations; failure to do so would imperil the nation's creditworthiness, causing potentially profound disruptions in already volatile global financial markets.
