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The interaction between depression and plasma Abeta(40):Abeta(42) ratio was associated with lower memory score (beta = -1.9, SE = 0.7, P =.006) after adjusting for potentially confounders.
Potentially confounders will be included in the model to adjust for these variables.
As can be seen in Figure 2, 49% of included references could be estimated to provide appropriate control for potentially confounders by considering factors from at least two of the three cited domains.
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* Potentially confounder (p value ≤ 0.10).
As our study was an observational study, we accept the possibility of residual confounding by potentially unknown confounders.
This hampers us to adjust for these potentially important confounders (residual confounding).
Nevertheless, any remaining confounder potentially able to influence our results considerably would need to (1) be strongly associated with breast cancer risk and the exposures that we studied, and (2) be unrelated to the potential confounders that were included in our models.
Nevertheless, any remaining confounder potentially able to influence our results considerably would need to (1) be strongly associated with breast cancer risk and with weight change in adulthood, and (2) be unrelated to the potential confounders that were included in our models.
The findings could also be attributable to uncontrolled confounding, although we adjusted for proxy measures of several potentially important confounders, including socioeconomic and early-life factors, and blood lead levels and maternal smoking during pregnancy.
Finally, we were able to include a range of potentially relevant confounders for the main analysis, as well as investigating the potential two-way interaction between age and gender, and mental distress on later dementia.
This is a very large study with virtually complete follow-up and with detailed information on potentially important confounders including smoking, deprivation, reproductive and hormonal factors, body size, dietary factors, and other health indicators.
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