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The focus is on drugs, which have the potential to partition (dissolve) in a lipid membrane but do not perturb membranes.
It suggests that ADMSC has the potential to partition a network into biologically meaningful modular structures and the modularity (a topological measure) does not necessarily reflect GO-based biological modules.
Consequently the paradox is resolved: proteins with a higher tendency to aggregate have stronger intrinsic potential to partition into membranes but the formation/accumulation of aggregates is not a prerequisite for this initial interaction with membranes.
As segments with high amphiphilicity exist in all proteins, our study successfully resolves the paradox by deciphering that the proteins with a higher tendency to aggregate have a stronger potential to partition into membranes through the same mechanism as α-synuclein to initially attack membranes to trigger pathogenesis without needing aggregates.
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Wildlife managers will benefit from the more complete genomic perspectives offered by advances in genomics technologies, as population-level genetic variation has the potential to be partitioned into categories of neutral variation, putatively adaptive variation, and potentially misleading variation.
Thus, a macromolecular chemical has the potential to alter the partitioning of chemical into the outer layers of skin, the first step in percutaneous absorption.
For instance, communities represented only by metagenomic data can be modeled using the pooled method which analyzes a community's total metabolic potential without attempting to partition enzymes to different organisms.
Boundary condition switching approach is applied to partition potential water fluxes into actual fluxes for the coupling between surface and sub-surface models.
Removing the north partition has the potential to improve glare on the rear space, yet it creates glare problems on the front side.
The organization of OMPs into islands and their segregation through binary partitioning has the potential to influence several aspects of bacterial cell envelope biology: (1) OMP memory.
Modeling a widespread species using biologically meaningful data partitions has the potential to greatly increase the performance of distribution models while only requiring basic manipulation in GIS software.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com