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This has mainly resulted from the identification of molecular alterations in relevant intracellular signaling pathways—Hedgehog, PI3K/AKT/mTOR, Notch, ErbB, MAPK and angiogenesis which are potential tailored targets for gallbladder cancer patients.
A potential tailored statin treatment based on the patient's CV and metabolic risk profile might emerge as the safest therapeutic approach.
The translational consequences of these findings for patients would be that pharmacological activators of the repressed potassium channels or antagonists of the up-regulated channels are potential tailored preventive treatments of the painful side effects of oxaliplatin.
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An example of a set of potentials tailored for deceleration from v i=760 m/s to a final velocity v f=300 m/s is displayed in Fig. 27(b).
Electrospun nanofibrous vascular grafts emerge as a potential tailor made solution to this problem.
More detailed kinetic studies of this MrSGT, using a number of sterol substrates, are essential for further investigation of its applicability as a potential tailoring biocatalyst.
Once all potential tailoring reactions have been detected and a subset selected for each structure in the library of hypothetical natural product structures, the original structure is modified by substituting one or more monomers, or by adding, removing, or changing the site of one or more tailoring reactions, in order to produce a derivative of the same in silico assembly line.
The lasiodiplodin cluster includes two genes encoding potential tailoring enzymes.
4. Determine lessons learned and improvements for global implementation, with potential tailoring by UN region and subregion.
Drug inclusion in a polymer depot also allows for potential tailoring of release kinetics, adding the benefit of being able to design the most efficacious delivery regimen.
Partner communication about HIV sexual risk behaviors represents a key area of epidemiologic and social importance in terms of infection acquisition and potential for tailored interventions.
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