PERV env peptides with potential specificity for the known PERV types are also described.
We performed additional analyses using non-cancerous disease controls and plasma from cancers other than colorectal to identify potential specificity issues.
Although the small sample size limited the statistical analysis, Western blotting validated differences in protein detection identified by LC-MS/MS suggesting the method's potential specificity.
We swapped several potential specificity residues in the RING domain between Roc1a and Roc2, but were unable to alter the Cullin binding (data not shown).
To further explore the potential specificity of the antibiotics for FoxM1-dependent transcription, we tested how Siomycin A and thiostrepton affect the transcriptional activity of other transcription factors such as p53, Tcf/Lef and GLI.
Even more relevant with respect to the potential specificity for breast cancer with a basal phenotype is a recent population based study showing a reduction in ER/PR negative breast tumors in women treated with lipophilic statins such as Simvastatin [49].
To check the potential specificity of MLSA, MLMA, and MLCwA, we selected serum samples with appropriate antibody titer which was given by indirect ELISA.
However, when the number of reads per contig is considered in relation to the tissue specificity of each library, many of the contigs obtained show potential specificity.
