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By contrast, primary granule fusion with the plasma membrane instead leads to hyperexocytosis and potential reprogramming (3), a third fate that further emphasizes the functional plasticity of human neutrophils.
We next tested whether our protocol was suitable for quantitative analysis of potential reprogramming factors, including those implicated in maintaining pluripotency and in early embryo development: Oct4, Sox2, Nanog and Sall4 [23] [25].
These results, however, should be cautiously interpreted as potential reprogramming of fibroblasts into myelin-expressing cells, because the expression of myelin genes did not reach the levels reached in myelinating cells and was characterized by the co-existence of transcriptional inhibitors and activators.
HBx-mediated upregulation of G6PD and potential reprogramming of hepatocyte metabolism may bring new insights into the field.
The imbalance of Th1 and Th2 phenotypes at the lymphocyte point of response may also explain our observations in addition to potential reprogramming of antigen-presenting cells.
The potential reprogramming of gene expression by HDACIs to elicit the gene networks observed here would be expected to alleviate metabolic consequences of pathological cardiac hypertrophy.
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Thus we investigated the potential reprogramming-promoting activity via combinations of inhibitors of these pathways.
Despite the potential that reprogramming technologies bring, there are remaining concerns preventing their broad application in the short-term.
This suggests kill-switches would temporarily disable handsets rather than permanently 'kill' them, which in turn suggests there may be some potential for reprogramming of the software to circumvent the kill-switch.
Our results showed that Oct4/ATSC can increase developmental potential following reprogramming via the overexpression of the embryonic transcription factors, Rex1, Oct4, and Oct4-dependent Nanog and Sox2.
Our results show that ATSC can undergo an increase in developmental potential following reprogramming via the overexpression of the embryonic transcription factor, Rex1, Oct4, and Oct4-dependent Nanog and Sox2.
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