Sentence examples for potential prolongation from inspiring English sources

In isolated, beating hearts, carbachol did not prolong action potentials per se, but caused bradycardia and rate-dependent action potential prolongation.

Attenuation of the slow component of delayed rectification, action potential prolongation, and triggered activity in mice expressing a dominant-negative Kv2 alpha subunit.

The role of IKs in disease and drug treatments is elucidated (the prevention of excessive action potential prolongation and development of arrhythmogenic early afterdepolarizations).

The treatment is geared toward prevention of thrombotic events, normalization of blood counts, control of disease-related symptoms, and potential prolongation of survival.

Blockade of two-pore-domain potassium (K2P) channels in the heart causes action potential prolongation and may provide antiarrhythmic action in atrial fibrillation.

Further analysis indicated a multifactorial action potential prolongation by quinidine: (1) decreasing fast repolarization with IC50 of 1.1·10− 6 M; (2) reducing maximum upstroke velocity with IC50 of 2.6·10− 6 M; and (3) suppressing spontaneous activity with EC50 of 3.8·10− 6 M.

The potential for prolongation of the QTc interval is the most notable adverse effect.

We find that simulation of action potential duration prolongation, at therapeutic concentrations, provides improved prediction of the TdP risk associated with a compound, above that provided by existing markers.

Moreover, in response to multiple ion channel blocker, vernakalant, and Kv1.5 blocker, XEN-D0101, hESC-atrial but not hESC-ventricular CMs showed action potential (AP) prolongation due to a reduction in early repolarization.

Individual macrolides vary in their potency of IKr inhibition and thus potential for QT prolongation and, therefore, potentially have different pro-arrhythmic properties.

As expected, application of IKur blocker produced pronounced action potential duration (APD) prolongation in atrial myocytes.