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Potential pathogenic mechanisms are discussed.
Although the causes of coronary ostial stenosis are not clear, various reports have suggested potential pathogenic mechanisms.
The aim of this study is to identify genetic variants influencing risk to CH and to explore the potential pathogenic mechanisms.
Therefore, it appears as critical to gain insight into potential pathogenic mechanisms associated to failure to clear lactate, especially in hyperdynamic septic shock patients in whom a low flow state is by definition a less probable mechanism.
The present study addresses potential pathogenic mechanisms by which this virus injures the CNS using a neonatal mouse model that mirrors congenital brain infection.
The recent identification of several genes with mutations linked to familial forms of PD has provided unprecedented opportunities to discover potential pathogenic mechanisms and to rationally develop more effective therapies [5].
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Further attention should thus be paid to IL-6 as a potential pathogenic mechanism in NASH.
In a second potential pathogenic mechanism, a transient infection may lead to a self-perpetuating innate immune response.
One potential pathogenic mechanism underlying the ALS8 mutation would be recruitment of normal endogenous VAP into aggregates, thereby depleting the cell of wild type protein.
The first DNA microarray study of autism identified ∼30 genes as differentially expressed in the cerebellum from autopsy tissue of autistic and normal subjects, and focused on the abnormal expression of the glutamate receptor as a potential pathogenic mechanism [51].
Although these observations have not been further explored as a potential pathogenic mechanism, we have now shown that L. pneumophila infection of D. discoideum results in the destruction of the mitochondrial large subunit ribosomal RNA (LSU rRNA).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com