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Furthermore, OA seems to be associated with changes in the quantity, phenotype, and differentiation potential of resident mesenchymal cells, fundamental for the injury healing process and tissue homeostasis maintaining (Nöth et al. 2008).
Therefore, the combination of low dosage simvastatin and NF-PLLA scaffolds appears to be a promising strategy for dentin regeneration with inflamed dental pulp tissue, by minimizing the inflammatory reaction and increasing the regenerative potential of resident stem cells.
By building on the hidden regenerative potential of resident stem cells, ERM circumvents the complex processes involved in tissue engineering and thereby facilitates the development of clinically translatable regenerative approaches.
Finally, because small molecules are relatively inexpensive, can penetrate many cell layers, and may be orally bioavailable, pharmacologic modulators of key developmental pathways will prove to be useful, not just to control differentiation of pluripotent stem cells in vitro, but also to enhance the regenerative potential of resident stem cells in vivo.
Strategies that aim to harness the regenerative potential of resident neural precursor cells (NPCs) are particularly promising.
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In other words, the "one-size-fits-all" approach to residency training could be seen as the main problem, and the proven learning potential of residents in difficulty as the solution.
This allows for observations about potential effects of resident participation in surgical care during training.
Given the often front line role that resident physicians have in patient care on weekends, we performed an analysis to delineate the potential effect of resident trainees on disparate outcomes based on day of admission.
Facility level characteristics such as size of facility, size of unit and ownership model (public, private for-profit, voluntary not-for-profit) are also potential predictors of resident outcome.
A major utility of direct reprogramming is the potential of harnessing resident support cells within damaged organs to regenerate lost tissue by converting them into the desired cell type in situ.
The investigation was planned by taking into account that the pathophysiology of bone healing mainly depends on the osteogenic potential of the resident cells, although several factors play a crucial role in restoring the normal bone structure.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com