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To solve the model, a hybrid genetic and simulated annealing algorithms is developed because of the high potential of outcomes to be trapped in the local optima.
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As mentioned above the potential of outcome predicting systems concerning the judgment about an individual therapy may be limited.
But when dealing with macroeconomic events or forecasting stockmarket movements, you do not know the potential distribution of outcomes.
"This is a complex system with a lot of potential trees of outcomes.
This potential correlation of outcomes results in a loss of independence of observations.
A range of baseline measures will be assessed as potential moderators of outcomes.
Further prospective studies are required to investigate potential predictors of outcomes in these patients.
Potential clustering of outcomes will be explored considering random effects at a hospital level.
Second, we used the statistical technique of generalized estimation equations, which compensates for potential correlation of outcomes within ICUs.
Furthermore, to account for potential correlation of outcomes within centres, we used generalised estimation equations with exchangeable correlation.
To account for potential correlation of outcomes within ICUs, we used generalized estimation equations with robust variance estimators [ 20].
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