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In vitro cultured hMSCs gradually lose their potential of differentiation and self-renewal.
Another clonal pulp cell line, H8, is a monopotent progenitor that displays a restricted potential of differentiation towards the odontoblastic fate (Lacerda-Pinheiro et al. 2012).
These results mean that patient-derived iPSCs have a potential of differentiation into tissues like other stem cells.
hADSCs potential of differentiation towards the adipogenic lineage was assessed at 3, 7, 14, 21, and 28 days after induction.
Mesenchymal stem cells (MSCs) are bone-marrow-derived progenitor cells, widely investigated for their potential of differentiation towards multiple lineages, such as osteocytes and chondrocytes.
Interestingly, using quantitative analyses, our results show that the potential of differentiation towards osteocytes were significantly reduced in synovium-derived MSC.
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These results suggest that Hes1-sustained cells still maintain the potential of neuronal differentiation on day 4 after differentiation.
This is also a potential area of differentiation for the startup.
iHepSCs can be stably expanded in vitro and possess the potential of bidirectional differentiation into both hepatocytic and cholangiocytic lineages.
Finally, Tat and/or Nef decreased the MSC potential of osteoblastic differentiation.
These data highlight the potential of combining differentiation inducers and MYB inhibition to lead to new breast cancer therapies.
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