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Acting under the assumption that overexpression of FRG1, FRG2 or ANT1 plays a causative role in the development of FSHD, transgenic mice were generated expressing each of these individual genes under the human skeletal actin promoter, specific for expression in muscle, which resulted in the identification of a potential mouse model for FSHD.
This potential mouse promoter region, like the corresponding human region, lacks a classical TATA box.
We also present a potential mouse Txnrd1 promoter region and compare this genomic DNA sequence with the recently studied TXNRD1 gene promoter [ 18] to identify conserved sequences.
In summary, the large collection of symptomatic double-mutant mouse lines has greatly expanded the armory of potential mouse models for preclinical studies.
We recognise that providing intelligent tools by which, for example, a clinician can search with disease terms to identify potential mouse models of interest, will be essential.
The 50 highest up-regulated transcripts before removal of the 14 cross hybridizing probe sets are shown in Table 2, with transcripts showing potential mouse artifacts identified.
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To see whether the 35/75 pool displayed this potential, mice were infected with a sub-lethal dose of bacteria (105 CFU/mouse) and one week later treated with the 35/75 pool.
The study was designed to investigate whether thio-Cl-IB-MECA has an anti-inflammatory potential in mouse macrophage RAW 264.7 cells and mouse sepsis model in vivo.
A potential transgenic mouse model of DR named 'Akimba' has been developed recently by crossing Kimba mice with Akita mice (Rakoczy et al., 2010).
Rspo2 and Rspo3 genes were also identified for their oncogenic potential in mouse mammary tumor virus associated with mammary tumorigenesis in mice [ 32, 33].
It seemed to be some kind of craftspeople's collective, though all the merchandise looked the same — faux-primitive renderings of semirural small-town life on coffee mugs, greeting cards, T-shirts, and, in what could only be seen as a deliberate effort to deter potential buyers, mouse pads.
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