Sentence examples for potential modes of action from inspiring English sources

Overall, PARP inhibitors represent a potentially important new class of anti-cancer agents with two potential modes of action, as single agents causing synthetic lethality and as chemo-potentiating agents.

A regulatory model, miRNA targeting of intron-containing pre-mRNAs phased sRNAs—targeting of mature mRNAs is pre-mRNAs phasedfurther expandsRNAs targeting mofes of action of plant mature.

Over past decades, a number of quantitative structure activity relationship (QSAR) models have been developed to predict rodent acute toxicity [5 7], It is well-known that acute toxic effect results from multiple potential modes of action (MOA), and it is quite difficult to develop a universal model with reliable prediction accuracy to an extensive data set.

The results of this study have enhanced our understanding of 8-2 FTOH kinetics and metabolism and potential modes of action in the rat, which will guide the design of future studies for FTOHs and our need to define the mechanistic basis for the observed effects.

Inhibitions to these specific chaperones are seen as potential modes of action for efficient chemotherapy drugs or for reducing the spread of cancer.

Endocrine disruption is one of the potential modes of action of arsenic exposure.

Uncertainties in understanding all potential modes-of-action for asthma induction and elicitation hinders design of hazard characterization and risk assessment methods that adequately screen and protect against hazardous chemical exposures.

This global approach is expected to cope more adequately with the complex matrices (such as soils and sediments) and to display the variety of potential modes of actions and strategies of the exposed organisms.

Determining systemic dose in toxicology studies will increase the understanding of potential mode of action (MOA) reducing the use of animals by avoiding unnecessary additional MOA studies.

In addition, it has been shown that both compounds promote Ethidium Bromide (EtBr) accumulation in SA1199B, thus corroborating their potential mode of action as NorA inhibitors.

In addition, BRO therapy attenuated the increase in the pro-inflammatory eicosanoids PGE2, LTB4 and cysLT (Fig. 1b-d), suggesting that direct or indirect interference with the AA metabolic pathway could be a potential mode of action of BRO.