It's a kind of brotherhood, reckoned Williams as he set off on his two-year stint, the distinctive uniform opening doors as he hit the open road in time-honoured German fashion: on foot, and with no phone to warn potential masters of his arrival.
The new knowledge that's coming out of that the identity of new genes that are potential master modulators of genetic networks, and how those may actually also be very important for mediating disease processes speak to the remarkable potential that will be realized when the CC is completed.
To identify potential master regulators of genes selectively expressed in normal HSC, we performed sequence analysis of the genomic regions upstream of the 93 genes in the common intersect.
This study provides a comprehensive examination of gene activities in bovine embryos and identified little-known potential master regulators of pre-implantation development.
This indicates a transcriptional network in which Gata-3 regulates the transcriptional activity of oestrogen receptor α, and identifies Gata-3 as a potential master regulator of ductal elongation at puberty.
In addition, the transcription factor NF-KB was specifically identified as being a potential "master regulator" of melanoma invasion since NF-KB binding sites were identified as consistent consensus sequences within promoters of progression-associated genes.
We carried out RNAi experiments to further prioritize candidates within the Trem gene cluster as potential master regulators of the MMnet, by using small interfering RNA (siRNA) against Treml1, Trem2, D3ZDX3_Rat, and Treml2 genes that were differentially expressed between WKY and LEW macrophages, followed by quantitative real-time PCR assessment of ten trans-regulated genes from the network.
Intriguingly, an integrated analysis of germline polymorphism and expression profiling using a backcross of skin cancer resistant and susceptible mouse strains identified LGR5 as a potential master regulator gene of the hair follicle.
In keeping with the role of a potential master regulator, GR binds to the GREs in regulatory regions of many of these genes.
This leads to two possible explanations; 1) Different DR protocols impact upon different pathways, each of which are dependent upon specific regulators or 2) sub-optimal DR regimes can result in false-positive identification of potential master regulators.
