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We have two scenarios for a potential interplay of scl-CA1 and scl-CA2, which differ in the role of the secreted/membrane-bound scl-CA2.
Further studies are needed to elucidate the details of this mechanism of DM and the potential interplay of racial differences, anthropometric characteristics, and inflammation.
Further insights into a potential interplay of topology and utilization of domain interactions arise from correlations between a domains degree and strength.
To investigate a potential interplay of p53 and HDACi at the level of transcription, we determined the mRNA expression levels of p53 itself as well as of MDM2, MDM4 and p21 by real-time RT PCR.
The potential interplay of Slo3 and CatSper in sperm is reminiscent of the interplay in neurons between Ca2+-activated K+ channels and voltage-gated Ca2+ channels (Cav) (Prakriya and Lingle, 2000).
Given the importance of FAK in mammary tumour formation as shown using two independent strong oncogenes (Lahlou et al, 2007, 2012; Provenzano et al, 2008; Luo et al, 2009; Pylayeva et al, 2009) and the potential interplay of FAK and p53 in cancer, we assessed whether FAK was important in p53-mediated spontaneous mammary tumour development.
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Here we have detected the potential interplay modules of DNA methylation and chromatin modifications for T2D.
DOI: http://dx.doi.org/10.7554/eLife.03440.015 We then turned to investigate how expression level affects folding and its potential interplay with the speed of translation in determining the quality of folding.
In the future it will be interesting to determine the direct effects of TGFβ ligands on differentiated RPE monolayers and the potential interplay with other aspects of AMD such as oxidative stress and inflammation.
We remain of the opinion that there is little that would be gained from an extensive discussion of potential interplay with replication at this time, but in response to the next question we have added specific considerations and tried to make more clear that we have not excluded interactions with replication.
Taken together, these features make missense mutations in the carboxyl-terminal region of coagulation factors of particular interest for the investigation of the potential interplay between impaired biosynthesis and enzymatic function.
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Justyna Jupowicz-Kozak
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