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Thus, both Gln depletion and L‐ASNase may exert cytotoxic activity through depletion of TCA cycle intermediates and subsequent disruption of mitochondrial membrane potential integrity.
Considering the Gln addiction phenotype in Jurkat and Jeko cells, we investigated whether or not Gln is used as a carbon source to supply TCA cycle intermediates and is involved in the maintenance of mitochondrial membrane potential integrity.
" I daresay one of the benefits value wise will be strengthening my appraisal and revalidation folder in terms of ticking all the right boxes there" (GP6) A lack of professional trust in the true purpose and potential integrity of both the external peer feedback model and the national appraisal system was clearly evident for a significant minority of participants.
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In vitro studies have revealed CNTs disrupt the membrane potential, membrane integrity, metabolic activity and cellular reproduction [137, 138].
To examine mitochondrial membrane potential and integrity, we have immunostained MLL4 antisense-treated cells with cytochrome- c.
Bacteriocins are proteinaceous molecules that inhibit growth of similar or closely related bacteria species through lethal disruption of membrane potential and integrity [ 12].
To support our above observation, treatment of mitochondria with CsA attenuated the elevated swelling of the organelle under high JC15 levels, signifying restoration of membrane potential and integrity of the inner mitochondria membrane.
If confirmed, these data suggest a history of higher and variable SBP for very old adults may be useful to alert clinicians to potential lower integrity in selected tracts, whereas cross-sectional SBP measurements may obscure the risk of underlying white matter hyperintensities.
"It's a serious potential threat to integrity," Mounsey says, "which is why we're taking it seriously and treating it as such".
In addition, translating items creates the potential to lose integrity in the equivalency of what is being asked from one country to other country (Ram 2007).
Cell membrane potential and membrane integrity were analysed by flow cytometry after 2 and 24 hours in each reaction condition using staining with 5 μg mL-1 propidium iodide (PI, which enters cells with compromised membrane integrity) and 0.1 mg mL-1 Bis (1,3-dibarbituric acid) trimethine oxanol (BOX, which enters cells with depolarised membranes) as previously described by Whitehead et al. 2011).
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CEO of Professional Science Editing for Scientists @ prosciediting.com