Indeed, microtubule dynamics associated with HDAC6 have also been shown to be of broad potential interest in conditions of neurodegeneration.
We show that BK channels in LNCaP cells may open at resting membrane potential, even in conditions of low cytosolic Ca2+ concentrations.
This complicates consideration of factors that may alter the shape or duration of action potentials as is likely to occur in conditions of hypertrophic cardiac remodelling.
Finally the 'immunological barrier' restricts and regulates the entry of circulating leucocytes, maintaining a low level immune surveillance of the CNS, and with the potential for concerted response in conditions of pathology (Greenwood et al., 2011; Hawkins and Davis, 2005; Persidsky et al., 2006; Stanimirovic and Friedman, 2012).
Together these data highlight the importance of HIF-1α in coordinating appropriate and effective innate immune responses, but also identify a potential role for dysregulation of HIF in conditions of inappropriate or persistent inflammation.
Results of this study show a potential benefit for a low-GI diet in conditions of simulated weightlessness.
The deposition time was controlled at 40 min in conditions of a deposition potential of −1.5 V, in contrast to the Ag/AgCl reference electrode at room temperature.
To identify a potential effect of RanBPM on HDAC6 activity in conditions of proteasome inhibition, we analyzed acetylated α-tubulin in whole cell extracts (Fig. 6B).
However, hECFCs exhibit a robust angiogenic potential in oxygen conditions representative of physiologic, ischemic, or ambient air conditions, and these findings suggest that hECFCs may be a superior cell source for use in cell-based approaches for the neovascularization of ischemic or engineered tissues.
Potential changes in conditions e.g. implementation of new chiral selectors, requires screening of the entire set to retain the most enantioselective systems.
