Exact(3)
The lack of productive viral replication further improves the safety profile of MVA as a vector, minimizing the potential for reversion to virulent forms particularly if used in immunocompromised individuals.
At the same time, care was taken to achieve this with a minimum number of passages (maximum 3) to minimize the potential for reversion to replication at non-permissive temperatures.
Mandatory required characteristics for quality control are the following: genetic stability, potential for reversion to virulence, homogeneity, lack of contamination, typical cultural, morphological and biochemical properties, sensitivity to specific bacteriophage, 'residual virulence', sufficient quantities of live microbial cells or spores, immunogenicity and safety for sensitive animal model(s).
Similar(57)
Moreover, in this work, we found that both genes in the dapAX operon contributed to virulence of Y. pestis in mouse models of bubonic and septicemic plague, thereby reducing the potential for spontaneous reversion of virulence.
Within the context of our 11 gene HSPC network topology, several expression states that correspond to the differentiated cell types shown in Figure 3 can automatically revert to the stem cell state, suggesting a potential for spontaneous reversion of differentiated cells to the immature stem cell phenotype (details in Supplementary Table S3).
Due to the fact that oral rabies vaccines contain live, attenuated rabies virus strains with the potential for replication and reversion to the pathogenic form, all field isolates have to be tested in differential tests against vaccine strains.
We explore the effect of different transgression potentials for a fixed reversion function and s = 0.5.
"We should prepare psychologically and economically for reversion to the status of a normal nation".
I have always been impressed by the inexorable tendency for reversion to the mean in security returns.
For reversion, the βme (5 mM) and the Gly-Gly-His peptide (2 mM) were used.
Monitoring live influenza vaccines is important because the risk for reversion to pathogenicity remains.
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