The enhancer bears binding sites for Ac-Sc/Da (E boxes) and a potential site for repression by the E spl) bHLH proteins, targets of Notch signalling (N box).
The evolution of two, layered mechanisms to limit heterochromatin spread may reflect the need for cells to have robust mechanisms to limit its potential for deleterious gene repression.
In all the tumours, PAI-1 and miR-145 localised predominantly to the cytoplasm; localisation of the latter being a general prerequisite for repression potential (Bartel, 2004; Supplementary Figure 1).
There is a potential for intellectual and creative repression on a worldwide scale that George Orwell or Ray Bradbury could only have dreamed of when they envisioned the dystopian societies of 1984 and Fahrenheit 451.
Our data suggested the potential for Su z 2 to affect auto-repression by Myc, and despite the unexpected potential for a repressor to interfere with repression, we pursued the possibility.
Two potential explanations for these test-negative patients are 1) novel mechanisms for repression of UBE3A expression yet to be identified and 2) misdiagnoses of phenotypically similar conditions.
But any form of outright default creates the potential for contagion.Because it is more subtle, financial repression is more successful.
Therefore we investigated the potential for EtOH or INK128 to trigger translational repression through SG formation.
This is a decidedly less honorable rationale for repression.
Ethiopia is a one-party state renowned for repression.
