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The study of chromosome heterochromatinization may provide clues to the potential for prolonging the human lifespan.
Thus, treatment for lung cancer which offers the potential for prolonging patient survival must always be judged in the context of its effects on patient QoL [ 5- 8].
Moreover, there are few reports to indicate that adjuvant chemotherapy may improve patient survival rates, although Huang et al. reported that the use of MAID (mesna, doxorubicin, ifosfamide, and DTIC) for the treatment of ovarian fibrosarcoma has shown potential for prolonging patient survival [ 4].
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Similarly, nanocarriers offers significant potential for prolonged drug release in the lungs because they largely escape uptake by lung-surface macrophages and can remain in the pulmonary tissue for a long time.
The presence of modifying factors may predict the potential for prolonged recovery and require additional management considerations, including formal neuropsychological testing and diagnostic imaging [ 5].
This is because response rate, as assessed using standard criteria, may not be a good surrogate for OS if therapies have the potential for prolonged stable disease or other unconventional responses [ 39, 40].
However, if the potential for significantly prolonging survival by aggressive therapy exists, the patient may decide to continue with the therapy.
The shorter CBI and TRIG measures were considered as alternatives, but concerns were raised in relation to their potential to screen for prolonged or complex grief issues after the death.
49 This current contributes to prolongation of the plateau phase within the cardiac action potential, effectively prolonging repolarization and accounting for the resultant long QT interval.
At the single cell level, hypokalaemia significantly reduced transient outward (Ito) and inward rectifier (IK1) K+ currents, effects which accounted for prolonged action potential durations (APD) reported at the whole heart level (Killeen et al. 2007a).
Thus, inhibition of PI3K-AKT signaling shows potential for enhancing and/or prolonging the antitumor effect of BRAF inhibitors or other anticancer agents in melanoma brain metastases.
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