The aim of the study was to document the radiation doses to patients during the implantation of stents in various arteries and to discuss potential reasons for prolongation of radiological procedures.
Individual macrolides vary in their potency of IKr inhibition and thus potential for QT prolongation and, therefore, potentially have different pro-arrhythmic properties.
Compared to the initial lead 2, compound 28 exhibited reduced potential for QTc prolongation in a non-human primate cardiovascular safety model.
Optimal sequential use of agents with potential for survival prolongation as well as the optimal time point to initiate treatment remains uncertain.
On the basis of blinded clinical studies, open-label extensions, and postmarketing experience, precautions are in place for use of lacosamide due to the potential for dizziness, prolongation of the PR interval, second-degree or higher heart block, and atrial fibrillation and flutter.
Sixty-three percent of the panel recommended that in patients with metastatic CRPC progressing by PSA without evidence of radiographic progression and in the absence of symptoms and imminent complications, agents with potential for survival prolongation should be initiated within 4 8 weeks.
Similarly, macrolides/ketolides and fluoroquinolones are associated with QT liability, but azithromycin and ciprofloxacin stand out as not being associated with the potential for causing QT prolongation.
Importantly, it has been shown to have a much lower potential for inducing QT prolongation in comparison to two of the drugs in its class (dolasetron and ondansetron).
We were concerned at the potential for QTc interval prolongation with high doses of haloperidol [ 8], particularly as continuous infusion is not our usual practice.
No interim analyses are planned, but the DSMB will have access to the total number of primary end-points for potential prolongation of the study period or increase in the number of participants.
