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"The potential for proliferation and end-use violations are things we watch very closely," the official added.
In contrast to somatic cells, human-induced pluripotent stem cells (hiPSC), with their unlimited potential for proliferation and differentiation, may in principle enable this therapeutic scenario.
It has been reported that cryopreserved human MSCs can maintain their potential for proliferation and osteogenic differentiation in vitro.
This leads to in vitro aging, the accumulation of intracellular oxidative damage, and subsequently a decreased potential for proliferation and differentiation.
A simple surface modification was made using hydroxyapatite (HA) on the scaffold in order to enhance osteoconductivity and cellular adhesion21, and mesenchymal stem cells (MSCs), known as one of the most optimal cell sources for ACL regeneration due to their high potential for proliferation and collagen production22,23, were seeded onto the scaffold as cell therapy.
An unintended consequence of U.S. policy was to increase the potential for proliferation.
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Generally, the potentials for proliferation, self-renewal and multi-differentiation remained relatively stable even after a prolonged series of alternating episodes of cryopreservation and resuscitation.
So while the world focuses on the potential for nuclear proliferation between Pakistan, North Korea and Iran, Brazil has similar proliferation capability but is seen as a 'team player', getting a green light as one of the good guys from the IAEA and the United States, while actually having manipulated and emasculated both for its own benefit.
Since IR exposure is known to induce oxidative stress [ 17, 18], induction of this pathway was expected, but in combination with the potential for increased proliferation suggested by miR-155 expression, it may reflect a potentially dangerous, cancer predisposed situation in response to genotoxic damage.
Dr. Moniz discussed the state of nuclear power technology and the potential for escalating proliferation risks in light of current US-Russia tensions.
The recent development of open-source 3-D printers makes scaling of distributed additive-based manufacturing of high-value objects technically feasible and offers the potential for widespread proliferation of mechatronics education and participation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com