In addition, as patients were not stratified by time from diagnosis or background PAH therapy (robustness analysis), there was potential for imbalance between treatment groups.
First, this is a retrospective, non-randomised study, and there is potential for imbalance in key prognostic factors between patients who received anti-HER2 treatment and those who did not, which may give rise to biased results.
Because of the potential for imbalance between groups associated with losses to follow-up in the intervening years and non-response among re-contacted participants, we also adjusted odds ratios and absolute risk differences for several covariates using sequential multivariable logistic regression analyses.
In the absence of "timely action to ensure sustainability," the U.S. Bureau of Reclamation said in a 2012 assessment of the river basin, "there exists a strong potential for significant imbalances between water supply and demand in coming decades".
The trial adopted various recruitment and matching procedures in an attempt to prevent or limit the potential for major imbalances between groups [ 46].
22 23 This metric describes differences between group means relative to the pooled standard deviation; differences greater than 10% reflect the potential for meaningful imbalance.
For each of these three possibilities, different effects are characteristic: the preservation or disruption of regulatory control, the genomic context, the potential for dosage imbalance and, of course, the size of the duplicated fragment [ 18].
To manage the potential for osmotic imbalance, the genes for enzymes to synthesize the osmolyte glycine betaine from choline are present (genes 2071, 2072), as well as a transporter to take up choline (gene 969) or, bypassing synthesis, specific ABC transport systems for uptake of glycine betaine are present, (genes 614 616, 2073 2075).
It is also a lesson that has been reiterated over recent months, when Central and Eastern Europe came into focus once again, but for all the wrong reasons: the potential for its economic imbalances to throw the rest of Europe and the world even further off-kilter.
Also in randomized controlled trials (RCT) the use of adjusted estimates is suggested for example to account for potential covariate imbalances or since prognostically relevant covariates were considered for a stratified randomization [ 20- 22].
