Because of their relatively large size (approximately 150 kD), intact mAbs tend to have unfavorable imaging kinetics, relatively poor tumor penetration, and present with the potential for eliciting host antibody responses [2 7].
It should be noted that because these regions are so highly conserved, often the consensus for one clade perfectly matched the consensus sequences of the other clades or indeed the group M (Fig. 1C), enhancing the potential for eliciting globally relevant cross-reactive responses.
Importantly, EDIII has only a very low intrinsic potential for eliciting cross-reactive antibodies against heterologous DEN virus serotypes [ 38, 39], implicated in severe pathogenesis.
We hypothesize that an evolutionary trade-off exists in virus clinical presentation between a potential for strong gene expression and a potential for eliciting strong immune responses.
We propose that poor viral CUPrefs may be central to a trade-off between strong viral gene expression and the potential for eliciting protective immune response.
The idea of using a variety of exercises is important to elicit maximal contractions from the abdominal muscles [ 21, 26] and providing feedback and motivation to the participant are necessary to increase the potential for eliciting a maximum effort [ 27].
