The field of malaria is rapidly changing, with malaria transmission decreasing, partly due to other effective interventions, and the potential for an efficacious vaccine on the horizon.
14 15 A 2003 report recommended rigorously designed, adequately sized randomised controlled trials on treatments that showed some potential for being efficacious, including nebulised bronchodilators (adrenaline, salbutamol, or ipratropium bromide, alone or combined), oral or parenteral corticosteroids (preferentially dexamethasone), and inhaled corticosteroids (especially budesonide).
Perhaps further research on AMPK's regulation will lead to new activation strategies or to the development of compounds with isoform specificity or better pharmacokinetic profiles, finally unlocking the potential for a clinically efficacious AMPK activator.
In particular, the ongoing clinical success of the closest predicate device, the auditory brainstem implant, speaks directly to the potential for the safe and efficacious long-term implantation of a stimulation device directly on the pial surface of the central nervous system's tissues [ 36, 37].
For example, for the large numbers of individuals suffering symptoms of irritable bowel syndrome (IBS) where conventional treatment is often poorly efficacious, the potential for alternative evidence based therapies is considerable.
Although clinical trials conducted in real world settings involve complex strategies, decisions and tradeoffs, interventions tested in the setting intended for its use may have greater potential for rapid implementation and sustainability if proven efficacious and cost effective.
While the identification and prioritization of chlamydial antigens is a crucial prerequisite for efficacious vaccine design, it is likely that novel adjuvant development and selection will also play a pivotal role in the translational potential of preclinical Ct vaccines.
Though further studies are necessary to contingently state the diagnostic and prognostic potential of PBMC gene expression profiling in general and of the 8 gene PC classifier set in particular, our current results are promising and point toward the potential for peripheral blood mononuclear cells to be highly efficacious tools for improving the prognosis of one of the world's deadliest cancers.
If efficacious, this intervention has considerable potential for dissemination.
Given that treatment response can be predicted by DFA relatively early in the treatment course, these results demonstrate the potential for using pharmacogenomic analyses to identify the most efficacious treatment modality for a given patient.
