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AEs of particular interest include extrapyramidal symptoms (EPS), somnolence/fatigue, weight gain, effects on glucose and lipid metabolism, prolactin elevation and potentially prolactin-related AEs, and the potential for effects on growth and sexual maturation.
One of the critical factors in assessing long-term potential for effects in aquatic environments is the flux of metal from water to sediments and vice versa.
Furthermore, they underline the potential for effects in the field at pesticide concentrations greater than 0.01× acute toxicity to Daphnia and are thus in agreement with the assumptions underlying the standards set by the European Union uniform principle.
Effects have been reported in the field, in response to industrial emissions, and dose response experiments over several weeks in laboratory studies have clearly identified the potential for effects at ambient concentrations.
Early studies in California have been followed by more recent data from east Asia, but there is still a dearth of information on the potential for effects of PAN and related peroxyacyl nitrates on vegetation typical of regions around tropical and sub-tropical cities where PAN pollution is increasingly important.
Adverse events reported with intravenous L-arginine in these settings include modest dose-dependent effects on blood pressure, potassium and phosphate [15], [16] and a potential for effects on acid base status [14] and blood glucose [17], [18].
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And collectively, those of us in the development community should think hard about how we -- in our models and institutions -- must evolve to embrace and promote the emerging powers' potential for effecting positive impact regionally and globally.
Two stratified analyses were conducted to assess the potential for effect modification.
For this reason, we performed subgroup analyses and multivariate meta-regressions to explore heterogeneity and the potential for effect modification.
The latter analyses were also conducted separately for each geographic characteristic to assess the potential for effect modification based on these factors.
Furthermore, we assessed the potential for effect modification by cigarette smoking for the associations between the genotypes and bladder cancer risk.
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