The study results cannot be used to predict drug pharmacokinetics and pharmacodynamics but rather the potential for drug clearance as it pertains to changes in a dialysis prescription.
These changes with advancing gestational and postnatal age provide real potential for differences in drug clearance to be observed in neonates as compared to older children.
Exclusions included prior use of strontium ranelate or sodium fluoride, hypersensitivity to a bisphosphonate, potential for pregnancy, calculated creatinine clearance less than 30 mL/min, corrected serum calcium level of more than 11 mg/dL (2.75 mmol/L) or less than 8 mg/dL (2 mmol/L), active cancer, metabolic bone disease other than osteoporosis, and a life expectancy of less than six months.
The F.D.A. decision puts the Bexxar application, first rejected in 1999, back on track for a potential agency clearance in 2003.
This classical approach assumes that absorption, distribution, metabolism, and excretion processes are first order, but does not always take into account potential saturation clearance limitations for some chemicals, or that blood flow can limit clearance.
Advantages of this surgical approach include the potential for excellent exposure and tumor clearance, reliable postoperative function, and excellent cosmesis.
One direct consequence of higher mutation rates is the potential for extensive host polymorphism if clearance of deteriorating alleles from a population, sexual or clonal, is not efficient.
In this respect we previously published a case report of a preterm infant treated with carboplatin, highlighting the potential for marked changes in drug clearance with age and requirement for increasing doses of carboplatin to achieve defined target AUC values [17].
None of the remaining potential covariates significantly reduced the CV in the between-subject error for clearance, with the exception of serum creatinine.
It is possible that persistent immune complexes, due to ineffective clearance, have the potential for promoting or exacerbating autoimmunity.
Dose adjustment of telavancin is recommended for renal impairment because of increased drug accumulation with worsening creatinine clearance and the potential for increased accumulation of hydroxypropyl-beta-cyclodextrin, a solubilizing agent present in the intravenous formulation.
