Suggestions(1)
Exact(4)
In contrast to abasic substitutions that preserve the ribose backbone but lose the potential for base pairing, UNA substitutions preserve the potential for base pairing but have increased backbone flexibility.
This suggested that, as for the asRNAs examined here, there is the potential for base pairing of these convergent transcripts, with possible downstream regulatory implications.
Another strategy for disrupting the cleavage function of AGO2 is to remove the potential for base interactions entirely by using abasic substitutions.
Base pairing sRNAs generally fall into two groups: cis-acting sRNAs that have capacity for extensive base pairing, and trans-encoded sRNAs with a more limited potential for base pairing with their target RNA.
Similar(56)
Furthermore, most, if not all, viral TURBS have the potential for base-pairing between regions flanking Motif 1 [18].
Additional file 3 shows that when using A. salmonicida Spot 42 (excluding the terminator) and a sequence extending from -100 nt to + 50 relative to the pirin start codon as input sequences to the program, significant potential for base-pairing between Spot 42 and the 5' untranslated region (UTR) of the pirin mRNA is found.
As the service's practices are assessed by the Validator to be occurring or not occurring, there is potential for bias based in interpretation.
It has been suggested that Ψ residues may contribute to RNA stability by altering potentials for base stacking, and by offering an extra hydrogen bond donor as compared to uridine [12], [13].
Of the 65 cases, only 18 cases (28%) exhibited a potential for Watson Crick base pairing.
The genes were selected on the basis of their potential for regulation, based on analysis of the literature, and many were found to be stage-regulated.
Currently, this method reported the highest sensitivity for DNA detection using nanomaterials based sensing platforms, and hence appears to have good potential for genetic based early diagnostic applications.
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