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To evaluate the natural course of disease progression in patients with Sanfilippo syndrome type B (mucopolysaccharidosis type IIIB), identify potential end points for future therapy trials, and characterize biomarkers related to the disease.
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In addition, preliminary attempts were made to investigate ENM-mediated effects on cell motility as a potential end point for NP toxicity.
Siri could use developers as much or more as developers could use Siri, but there's a potential problem with allowing devs to use it freely and become a potential end point for users.
Investigators submitted all information relevant to any of the potential end points to the data centre for review by the end point committee, who were blinded to the treatment assignment.
Hemodynamic, echocardiographic, neurohormone, and exercise measures hold some promise as potential surrogate end points for clinical trials of therapy for pulmonary arterial hypertension.
In addition to piloting the vehicle safely, security drivers must survey the road and the beginning and end points for potential hazards or security threats, be able to summon authorities and back-up, and know where the local hospital is, he says.
As TKV cannot be used potential clinical trials will therefore need to establish novel and specific clear-cut primary end points for ARPKD.
The absence of fluorescence is a potential objective surgical end point for standardising the resection, and also facilitating interrogation of distinct tumour areas.
Data on six laboratory measures and five organ dysfunctions were systematically analyzed to identify a potential surrogate end-point for monitoring DrotAA therapy and predicting 28-day mortality at the end of therapy.
A validated surrogate end point for 5-year OS offers potential advantages for conducting clinical trials more efficiently and expediting development of new treatments.
It is therefore informative to use intentions to stop smoking as an end point for a study designed to assess the potential effectiveness of an intervention.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com