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Computational results, for a large number of instances derived from the literature, show that some instances with up to 88 customers and 8 potential depots can be solved in a reasonable computation time.
The computational evaluation on three sets of instances (34 instances in total), with 5 10 potential depots and 20 88 customers, shows that 26 instances with five depots are solved to optimality, including all instances with up to 40 customers and three with 50 customers.
Given a set of potential depots with opening costs, a fleet of identical vehicles and a set of customers with known demands, the classical LRP consists in opening a subset of depots, assigning customers to them and determining vehicle routes, to minimize a total cost including the cost of open depots, the fixed costs of vehicles used, and the total cost of the routes.
Lipid partitioning (i.e., the distribution of fat among its potential depots) is much more related to the metabolic phenotype of obese children and adolescents than the degree of obesity.
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Zhang et al. (2014) presented a mathematical model for a two-level supply chain network that includes multiple capacitated potential depot and a set of customers.
Next, we develop a general approach to determine the potential depot and biorefinery locations, and calculate the actual flow path distance between facilities using Geographic Information Systems methods.
The CLRP is defined by a set of potential depot locations, with opening costs and limited capacities, a homogeneous fleet of vehicles, and a set of customers with known demands.
In the present study, the first to investigate potential depot-dependent release of DPP4 from adipose tissue, visceral adipose tissue was by far the major site.
The majority of excess fat is stored in its conventional subcutaneous depot, yet other potential storage sites exist as well, such as the intraabdominal (visceral) fat compartment and insulin-responsive tissues such as muscle and liver.
Also, the potential locations for depots and treatment facilities are given (i.e., the set of depots and treatment facilities must be chosen from these potential locations).
Where N is the number of customers and M is the number of potential locations for depots.
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Justyna Jupowicz-Kozak
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