Sentence examples for potential common target from inspiring English sources
In contrast, the relative uniform overexpression of MELK in basal-like breast cancer makes it a potential common target in an otherwise heterogeneous disease.
Using a bioinformatics approach, we predicted potential common target genes for the up-regulated (FC > 5) miRNAs in xlpra2 at 16 wks.
This study provides the first identification of potential common target genes modulated by TRD treatment of cell lines originating from four different cancer types.
The aim of this study was to identify potential common target genes modulated at the transcriptional level following TRD treatment in tumour cell lines originating from different cancer types.
The mechanism of action for most of these drugs is unknown although, using computational methods we have recently shown that the antimalarials and SERMs may share some pharmacophore features which may be important to infer a potential common target or targets.
Forty-eight of the 54 'RITA-unique' p53 targets and 162 of the 173 p53 targets 'common for RITA and nutlin' have been found to contain conserved Sp1 RE, thus identifying them as potential common target genes of p53 and Sp1 (Supplementary Tables S5 and S6).
We were able to further identify potential common targets of miR-30 family with a role in survival and proliferation.
Therefore, it is probable that some of the potential common targets are either redundantly or synergistically controlled by GLD-1 and PUF-8.
Interestingly, further investigation of ChIP-seq data showed that around 71% of these potential common targets contained p53-binding sites in the vicinity (±500 bp) of the putative Sp1 RE.
Although two recent publications from our group have already focussed on microarray derived transcriptional profiling of TRD treatment in two single cell lines [ 16, 14], the current project provides the first microarray analysis which was performed simultaneously in five different and heterogeneous cell lines of four different malignancies to identify potential common TRD target genes.
Long et al. [26] proposed a GTL algorithm, which extracted the potential common themes between source and target domains and optimize maximum likelihood function to maintain the geometric structure of the documents.
