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Hence, it seems that activation and repression signals can be transmitted by ABI3 to these two target genes in head head orientation via a potential common promoter region.
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Interestingly, the genes T21 and T22 are in head head orientation to each other, and thus they have the potential to share a common promoter region.
In this orientation, the two corresponding genes have the potential to share a common promoter region depending on the distance between these genes (Fig. 1).
The role of aberrant methylation of the DPD or ERCC1 promoter as a potential common epigenetic regulatory mechanism in tumour cells remaining after oxaliplatin-based chemotherapy warrants investigation.
As a consequence, this class of integron is capable of capturing gene cassettes via this site-specific recombination platform, and gene cassettes are also able to be further expressed from a common promoter located in the 5′-conserved segment (5′-CS) region where two potential promoter sites Pc (also known as PANT) and P2 locate, with Pc approximately 200 bp upstream of the integration site [ 25].
Therefore an analysis of the promoter regions of the genes from list L235 was conducted in order to identify potential common transcriptional regulators.
Family was the most common promoter.
We have limited the number of predicted promoters/genes to the top three promoters that shared the highest number of common promoter motifs with the TGG.
Another simple constrained scenario arises from bidirectional gene pairs, which share a common promoter [9].
Moreover, since TFBSs in divergent promoters (a common promoter region shared by two divergently transcribed adjacent genes) cannot be assigned to one of the two adjacent genes unambiguously, I excluded these TFBSs from my analyses to avoid the potential bias.
Through analysis of promoter content of these 19 genes, we found genes that share a common promoter model and thus share common promoter elements (PEs).
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