The nucleoside antibiotic, 5′-O-[N- salicyl)sulfamoyl]adenosine (1), possesses potent whole-cell activity against Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB).
The reported PknB inhibitors were found to be less potent against whole cells as compared to the purified protein.
However, at low, physiological, leptospiral dose, living virulent complement resistant strains were consistently more potent in whole blood stimulations than the corresponding non-virulent complement sensitive strains.
Turnbull has shown you can turn around a whole potent political discussion by replacing apocalyptic dog whistling with rational, proportionate discussion.
The John Birch Society possessed such a mainstream message--the existence of a Communist world system with tentacles in the United States--that it had a potent influence over whole sections of the Republican Party.
Neither gases nor particles induced vascular LPO despite potent effects from whole vehicular emissions.
Our reasoning was that on very rare occasions, e.g. among people exposed to high doses of potent carcinogens, the whole population or a vast majority develops cancer.
Compound 2 was the most potent toward the whole cell parasite with an EC50 of 20 nM, and had an IC50 of 13 nM against TbGSK.
It's the most potent part of the whole redesign, and could seduce users who were losing their best friends' Stories amongst the noise.
Dubbed platensimycin, the compound was found to be a potent inhibitor of a whole range of so-called Gram-positive bacteria, including several of the "superbugs" plaguing hospitals, such as Staphylococcus strains resistant to every known antibiotic except vancomycin (ScienceNOW, 14 March 2002).
