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For example, the combination of GLP-1 with glucagon, targets GLP1Rs and glucagon receptors (GCGRs) on the beta cell (both Gαs-coupled), and in animal studies causes potent weight loss, perhaps by enhancing energy expenditure (via GCGR), whilst concomitantly reducing food intake (via GLP1R) [ 5].
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Douwe de Boer is the Dutch scientist Contador hired to write a report explaining how the consumption of contaminated meat might have caused Contador's positive test for clenbuterol, a potent weight-loss and muscle-building drug.
At the Tour in July, he also tested positive for a low level of clenbuterol, a potent weight-loss and muscle-building drug, but blamed the result on his consumption of tainted beef from Spain.
But on August 28th Roche decided to delay the drug's launch, expected this autumn, due to fears about breast cancer.With the market for a safe, potent weight-loss pill worth at least $5 billion in America alone, a number of firms hope to come up with drugs that tinker with the genes that contribute to making people fat.
The prospect of a potent weight-loss drug sparked a bidding war among biotech firms.
Most evidence demonstrated that α-lipoic acid is a potent weight-reducing and insulin sensitizing agent in human clinical trials and rodent models [ 101– 101].
12 13 However two of the most potent weight-inducing antipsychotics, clozapine and olanzapine, are also two of the most efficacious antipsychotic compounds, and especially clozapine is often used to treat patients resistant to other antipsychotics.
Manufactured derivatives of glucocorticoids such as betamethasone or dexamethasone are 25 30 fold more potent by weight than endogenous cortisol in terms of anti-inflammatory activity [ 2].
Originally, buprenorphine was thought to be 25 50 times more potent by weight than morphine in an equivalent dose (Jasinski et al 1978), but it is now thought that buprenorphine is 75 100 times more potent than morphine (Sittl et al 2006).
Two different respectively N-stearoyl and diacetylenic fatty acyl glutanamide were prepared and employed as both potent low molecular weight hydrogelators (LMWGs).
The most potent low molecular weight inhibitors of pancreatic RNase superfamily enzymes reported to date are synthetic derivatives of adenosine 5′-pyrophosphate.
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