Mr. Gober, whose career spans two decades, is a sculptor known for hand-crafted, psychologically potent transformations of commonplace objects.
π-Acid-mediated alkyne carboalkoxylations are potent transformations for the rapid assembly of substituted carbo- and heterocyclic frameworks from simple precursors under mild reaction conditions.
It is well established by NIH/3T3 cells transformation assays that PDGFB, but not PDGFA, is a potent transforming growth factor [ 4, 5], suggesting that the transformation process is mediated by PDGFRB.
Here phrase lengths rarely strayed from four bars or multiples thereof; melodic lines were driven from underneath by potent harmonic transformations.
The jars now contain ever more potent promises of transformation, as the old taboos against the hubris of trying to improve on nature are, like nature herself, everywhere on the defensive.
Other potent compounds whose transformation products might merit prioritization or at least closer scrutiny include chemotherapeutic agents, naturally occurring toxins, and allelochemicals.
Therefore, we would conclude that the ISCs are the most potent cells for transformation, but certainly not the only possible cells of origin for colorectal cancer.
Our findings demonstrate that the key aspects of human carcinogenesis closely recapitulating the features of the native tumors can be faithfully reproduced in vitro when an appropriate oncogene is used to transform its natural target cells; this in turn points to the fundamental role in malignant cell transformation of potent oncogenes expressed in the relevant target cells.
38– 48 PPM1D has been identified as a potent oncogene, enhancing mammary transformation in a breast cancer-susceptible animal model.
Cooney et al. found that γ-tocopherol was a much more potent inhibitor of neoplastic transformation in 3-methycholanthrene-treated 3-methycholanthrene-treated 3-methycholanthrene-treated
