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It is known to elicit potent toxicity against mammals and induce influx of Ca2+ into cells.
What's more, 1f exhibited potent toxicity against MCF-7 cells with IC50 at 0.003 μM and against 7721 cells at 0.115 μM, respectively.
In 1935 he began his search for an "ideal" insecticide, one that would show rapid, potent toxicity for the greatest number of insect species but would cause little or no damage to plants and warm-blooded animals.
Although the scorpion venom from the Buthidae family with the potent toxicity attracts more interests, toxins from the non-Buthidae family draw great attention as well because of its abundance and complexity even without harm to mammals.
The presence of amyloid oligomers in muscle cells has been shown to have potent toxicity [42].
However, the two C-terminal fragments 2 and 3 impaired the neurite growth, suggesting that these two fragments have relatively potent toxicity.
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Notably, the most common toxicity was observed in hematologic compartment, suggesting a more potent toxic effect on hematologic malignancies.
Although oil-in-water emulsions, such as Freund's adjuvant (FCA/FIA), are known to be potent, their toxicity and reactogenicity make them unacceptable for human use.
The potent developmental toxicity of dioxin in multiple species has been known for a number of years.
These species possess type II venoms with potent lethal toxicity, so the possibility of prey wandering a significant distance from the attack site before it has succumbed to venom is much less likely than species exhibiting type I venom, making relocation following a strike less challenging for these highly toxic rattlesnakes.
Combretastatin A4 Phosphate (CA4P) is a tubulin-binding VDA that displays potent and selective toxicity towards tumour vasculature (Tozer et al, 1999).
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CEO of Professional Science Editing for Scientists @ prosciediting.com