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In addition, SsPETE2-expressing plants exhibited more potent tolerance to oxidative stress than plants overexpressing AtPETEs, likely owing to the stronger copper-binding activity of SsPETE2 than AtPETEs.
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Among PF40s-treated groups, the higher dose-treated usually had more potent insulin tolerance than that of the lower dose and medial dose why it decreased blood-sugar steadily avoid abnormally low blood sugar usually resulting from excessive insulin.
However, mucosal surfaces are endowed with potent and sophisticated tolerance mechanisms to prevent the immune system from overreacting to the many environmental antigens.
In conclusion, our results show that DCs were very potent at breaking tolerance against endogenous mPrP and favor the production of high titered antibodies against its native conformation over T-cell responses resulting in substantial delay in disease progression without triggering autoimmune reactions.
We tested if Hp91 when delivered in PLGA-NPs would be sufficiently potent to break tolerance and induce potent CTL responses in vivo.
It is also well known, however, that immature DC can act as tolerogenic DC and are also potent inducers of tolerance in an antigen-specific manner [ 23, 24].
Finally, treatment with antigen-conjugated PLG-PEMA particles was also potent at inducing tolerance in disease mediated by the transfer of a large number of highly activated encephalitogenic T cells, demonstrating its potent therapeutic efficacy.
In summary, we describe a simple, yet highly efficacious, method for inducing potent T cell tolerance for the prevention and treatment of EAE employing iv infusion of antigen-coupled PLG-PEMA nanoparticles.
The major advantages of NAs are good tolerance and potent antiviral activity associated with high rates of sustained on-treatment response to therapy.
CD4+ Treg cells are considered as key mediators in the maintenance of immune tolerance and potent modulators of T cell-mediated immune responses [5].
Among the different pollutants tested, polycyclic aromatic hydrocarbons were often the most potent for increasing insecticide tolerance, possibly due to their ability to induce detoxification enzymes [ 31].
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