Sentence examples for potent sustained from inspiring English sources

In this report, the ability of PEG-SN38 to down-regulate HIF-1α and its downstream targets, in a more potent, sustained manner compared with CPT-11 was examined.

Consistent with this rationale, the authors report that new peptides with varying ratios of agonism both at glucagon and GLP-1 receptors have potent, sustained satiation-inducing and lipolytic effects in rodents (Day et al., 2009).

A new ARB, azilsartan, was recently approved and is expected to exert a more potent, sustained for 24 h BP-lowering effect compared to existing ARBs (candesartan cilexetil, olmesartan, telmisartan, valsartan, and irbesartan) [ 21].

After treatment it was found that EZN-2208 induced potent, sustained HIF-1α down-regulation (37% at 48 h and 83% at 120 h) in the tumors, whereas CPT-11 caused only minor, transient HIF-1α down-regulation.

Conversely, DPP-4i therapy is not associated with inhibition of gastric emptying or weight loss, and the available data suggest that long-acting GLP-1R agonists achieve more potent control of glycemia, relative to DPP-4i, due to more potent and sustained GLP-1R activation.

Additional costimulatory domains, incorporated into CARs, are indispensable for engineering T cells that show a potent and sustained antitumor activity (Dai et al., 2016).

This modified electrode exhibits potent and sustained electron-mediating behavior and a well-defined reduction peak in response to methylglyoxal was observed.

Thus, this PAF receptor antagonist exhibits potent and sustained neuroprotection that may be of value for the design of stroke therapies.

While inhibition was achieved with all of the reagents tested, only the commercially available "self-delivery" modified Accell-siRNAs (Dharmacon) produced potent and sustained in vivo gene silencing.

These include increased sharing of hypotheses and data, articulating complementary research styles, and mutual advocacy for early, potent, and sustained involvement in mission planning and execution.

As areas of high tuberculosis and HIV-1 prevalence partly overlap, novel tuberculosis vaccines should induce potent and sustained anti-mycobacterial responses early in life, while preferably using non-replicating vaccines to avoid safety issues in neonates and immunodeficient patients.