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We have explored replacments for the isoleucine residue in the pY+3 pocket and thus identified 1- R -amino-3- S -indaneacetic acid as the most potent replacement.
Lipopeptides are known to show bactericidal activity and due to their simple structure, ease of design, and low cost of implementation, they are often considered potent replacement for many traditional antibiotics.
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Mesenchymal stem cells (MSCs) have attracted much attention in regenerative medicine owing to their apparent usefulness as multi-potent replacement cells.
The SERM is structurally very similar to levormeloxifene, which has been tested clinically in postmenopausal women and found to be more potent than hormone replacement therapy in preventing bone loss [ 27].
Our negligence has resulted in the replacement of one potent neurotoxin, lead, with another, PM2.5, derived almost exclusively in places like London from diesel-powered vehicles.
We demonstrated that IGF-I is a potent regulator of lifelong neuronal replacement in the mouse olfactory system.
Though the initial hits discovered by phage display showed only moderate inhibitory behavior, it was possible to develop them into more potent compounds through amino acid replacement, truncation, and chemical modifications.
The annual cost of potent anticoagulants in these joint replacement patients across England and Wales is approximately £13 million (For example Clexane (Sanofi-Aventis Ltd, Paris, France) £3.03 per 40mg (daily) syringe, 14 days for 90 842 knee replacements and 35 days for 86 488 hip replacements), and this ignores community nurse fees to administer the drug to large numbers of patients.
However, our data suggest that renal failure requiring renal replacement therapy is as potent a risk factor for reactivation of TB as any (including HIV infection) previously described.
Only one of the case studies, Katz et al [ 26], argued that the treatment described; (total joint replacement), could offer a potent and systematic treatment strategy in the palliative care of patients with advancing progressive disease and concomitant musculoskeletal pain.
Pyrethroids are selected as replacement pesticides because they are potent insecticides with relatively low mammalian toxicity (Ray and Fry 2006).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com