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Mianserin alone, as well as in a combination with sildenafil at the highest dose, caused a potent reduction in locomotor activity.
The evidence supporting the role of increased extrahypothalamic CRF being associated with decreased delta sleep includes studies in which intracerebroven-tricular administration of CRF in adult rats results in a potent reduction in delta sleep (Ehlers et al, 1986; Chang and Opp, 2001).
Accordingly, in our study a potent reduction in basal mechanosensitivity was limited to the mice that received the drinking water containing the high doses of caffeine (0.3 and 0.6 mg/ml) (Fig. 1B, Before acupuncture), implying the involvement of systemic changes in the central and cardiovascular systems.
Fig. 3D shows that treatment with MS 479, results in a potent reduction in lung-human alu sequences, indicating the presence of fewer disseminated cancer cells.
FACS analysis showed that cPAF exposure induces a potent reduction in DNA synthesis, and a significant arrest at G2 M.
Of note, the potent reduction in revascularisation with new generation drug eluting stents was not associated with any safety concerns.
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LNA-mediated PCSK9 mRNA inhibition displayed potent reduction of PCSK9 in cell lines and mouse liver.
Sunitinib produced a more potent reduction of tumour burden in the 786-O cell line, which may be due to its VHL−/− status.
They're cooked in a potent reduction sauce of Amarone wine, then served with a heap of spinach sprinkled with pine nuts and raisins.
We show that ETP-45658 treatment resulted in a rapid and potent reduction of AKT phosphorylation on serine residue 473 and the concomitant reduction of FOXO3a phosphorylation.
A potent reduction of the secondary response was still observed in Langerin/OVA-pre-treated mice (Fig 6A, left).
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