Nucleosomes constitute a potent obstacle for biological processes requiring access to DNA, such as transcription, DNA replication and repair.
But Mr. Long, the chairman of the state Conservative Party, has emerged this year as the single most potent — and immovable — obstacle to the legalization of same-sex marriage in New York.
While there are several specific OGA inhibitors, the complexity, high cost, and limited versatility of classical OGT assays, in addition to the enzyme's instability during purification, have been major obstacles in developing potent and selective OGT inhibitors.
Obstacles are strong nevertheless.
Theoretically, infusion with large numbers of potent suppressor cells may present a serious obstacle to the induction of effective immune responses towards infectious pathogens and a reduction in immune surveillance against tumour cells.
However, it is often the less anthropophagic, and correspondingly less potent, primary vectors that usually present the greatest obstacle to malaria elimination.
These obstacles were overcome first thanks to a potent anti-Vel, which we succeeded to use for Western blot analysis.
Despite this undertaking, both domestic and international audiences have noted China's limitations and obstacles, and the countervailing voices promoting Internet freedom are equally potent.
As these obstacles have become a clinical reality, even with the use of potent anti-retroviral regimens, the need for novel therapeutic strategies specifically targeting HIV-1 latency is evident.
Structural reforms to strengthen competition and reduce price inertia would make monetary policy more effective.The second obstacle is that monetary policy tends to be a less potent weapon in the euro area than in America or Britain.
