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However, the potent nature of the cytotoxic payload creates associated manufacturing challenges for active pharmaceutical ingredient (API) manufacturers, because huge investment in containment technology is required to ensure the protection of operators and the environment.
Considering the potent nature of IL-1 β and IL-18, it is understandable that inflammasomes require regulators to control activation and efficiently subside inflammatory signals.
Given that potent nature of the pigment, it is beneficial for pathogens such as GBS, which typically exist as commensals in the lower genital tract, to repress pigment expression to minimize host injury.
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These features of GBM are attributed to presence of a significantly smaller proportion of glioma stem cells (GSCs) that are endowed with self-renewal ability, multi-potent nature and show resistance to therapy in patients.
The awareness of their true toxic origins and potent pharmacological nature is emphasized by their 'select agent' classification by the US Centers for Disease Control and Prevention.
Most anticancer agents are poorly water soluble and highly potent by nature, leading to nonselective devastation of tumor, as well as normal healthy cells; this poses an obstinate challenge in safe and effective tumor chemotherapy.
Flavonoids are very important for the treatment of many diseases due to their potent antioxidant nature.
Antioxidants, such as superoxide dismutase (SOD), are among the most potent in nature in protecting living systems against oxidative stress.
This again demonstrates the potent paracrine nature of the interaction between the cytokines and their receptor in the microenvironment of the tumour.
Determine if Fc-fusions to Ags make useful vaccines for diseases other than those caused by viruses, and whether polymeric versions are even more potent by nature of their increased avidity binding.
Naive CD4+ T cells are multi-potent in nature and have an ability to differentiate into distinct effector and regulatory subtypes that express lineage-specific regulators, including transcription factors and signature cytokines.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com