Sentence examples for potent methodology from inspiring English sources

Thus, the combination of stimulation with modern imaging techniques may be a particularly potent methodology for the non-invasive mapping of the functional connectivity of the brain.

Hence, a well established nontoxic and ecofriendly potent methodology for the synthesis of nanoparticles has mounted to a level of supreme importance [ 8– 11].

Remarkably, when primary amines other than anilines were selected for this transformation, no reaction was observed and they are not potent nucleophiles in this methodology; this could be attribute to the higher nucleophilicity of the acyclic primary amines poisoning the catalyst as a result of competitive binding with the primary amine to the boric acid.

Immunological concerns that surround viral delivery, less potent delivery by nonviral methodologies, and concerns over the manufacture of recombinant vectors must all be addressed to placate regulatory bodies.

This scaffold was used as a template in a focused combinatorial library, designed using the NMR SOLVE methodology, to prepare potent (50 200 nM) biligand inhibitors for multiple dehydrogenases.

Ultimately, as phenotypic screens have been successful tools for discovering potent antibacterial drugs, the HT-SPOTi methodology has the potential to identify new antimicrobial molecules with clinical relevance.

A very active field for the search of more efficient anti-TB chemotherapies is the use in silico methodologies for the discovery of potent anti-TB agents.

Because selectivity is the major concern, both ligand-based and protein-based pharmacophore methodologies were used to identity potent and selective MMP-13 inhibitors.

These results provide new evidence confirming that Tcf3 is a potent negative regulator of pluripotency and validate a forward screening methodology to identify modulators of pluripotent stem cell biology.

The results obtained by combining these methodologies give insights into the key features for designing more potent analogs against HIV.

Furthermore, computational algorithms and multiple confirmatory assay formats combined with high-throughput screening methodologies greatly contribute to the identification and characterization of novel potent drug targets [ 67].