But they're also uniquely potent messengers.
PA, a potent second messenger by itself, can be dephosphorylated to Diacylglycerol (DAG), or hydrolyzed to Lyso-phosphatidic acid (LPA), by Phosphatidic acid phosphohydrolases and Phospholipase A2 respectively [13] [17].
The physiological actions of NO are mediated predominantly via the activation of soluble guanylyl cyclase leading to generation of the potent second messenger cyclic guanosine monophosphate (cGMP) from guanosine 5'-triphosphate (GTP) [2], [3].
Adenosine is a potent extracellular messenger produced in high concentrations under metabolically unfavorable conditions [ 1].
PIP3 is a potent second messenger that recruits certain kinases to the plasma membrane including the Protein kinase B/Akt family of kinases and PDPK1.
One of the most enigmatic questions on CD38 is the role of its enzymatic activity in catalyzing the conversion of NAD+ to cADPR (a potent calcium messenger) and ADPR (whose role has not been established, but may have inhibitory functions) 6.
Rappers, too, Ms. Wright says, are "among the most potent new messengers of political change": hip-hop has emboldened the young — in places like Tunisia, Morocco, Saudi Arabia and Palestinian villages in Israel — "to lash back at both extremists and autocrats," and "its songs have become the anthems of protests across the Arab world".
Androgen-metabolizing enzymes convert cholesterol, a relatively inert molecule, into some of the most potent chemical messengers in vertebrates.
Both products of the enzymatic reaction, 1,2-DGs and inositol-1,4,5-phosphate (IP3), are potent second messengers.
NAADP (nicotinic acid adenine dinucleotide phosphate) is a potent Ca2+-mobilizing messenger, active in a wide variety of cells [ 1– 4].
