Sentence examples for potent manner from inspiring English sources

5– 10 Together, these mechanisms integrate to improve glycemic control in a potent manner.

We demonstrate that CMDB7 acts on both tumour and endothelial cells, decreasing in a potent manner the tumour growth and angiogenesis in vivo.

Its addition to a mixture of Aβ peptides was shown to accelerate the formation of Thioflavin T-positive amyloid structures in vitro, in a more potent manner than did Aβ42 or Aβ40 [ 29].

CMDB7 acts directly on both tumour and endothelial cells, decreasing in a potent manner the tumour growth by increasing the proliferation of tumour cells and especially angiogenesis in vivo.

The results of the present study indicate that FPR1 haplotypes carrying a single amino acid substitution of leucine for valine at position 101 possess significantly higher affinities for CsA and CsH, thereby inhibiting fMLF-induced calcium mobilization, chemotaxis and MAPK phosphorylation in a more potent manner.

However, recent lineage tracing studies disagree on whether multi-potent cells actually give rise to the various mammary epithelial lineages during development and reproductive cycles in vivo, or whether lineage-restricted progenitor cells are induced to behave in a multi-potent manner in transplantation studies [ 12- 14].

In this report, the ability of PEG-SN38 to down-regulate HIF-1α and its downstream targets, in a more potent, sustained manner compared with CPT-11 was examined.

To create stable cell systems in which Mps1 could be inhibited in a potent and reproducible manner, we stably expressed LAP-Mps1M602A (hereferredreferred to as Mps1as) or LAP-Mps1M602G in UTRM10 (U2OS-derived) and HCT-TRM (HCT116-derived) cell lines in which endogenous Mps1 could be removed by doxycycline-induced expression of Mps1 shRNA [17].

Thus, a continued delivery system of SN38 by EZN-2208 can down-regulate HIF-1α in a more potent and sustained manner compared to CPT-11.

Moreover 64 and 67 were shown to act in a potent and selective manner on Mcl-1/NOXA-B over Bcl-xL/BH3 in both biophysical assays and a cellular context a selectivity profile which is challenging to achieve.

Thus, we hypothesized that, due to favorable pharmacokinetic and biodistribution properties of EZN-2208, this molecule will work as a sustained delivery system for SN38 and, therefore, will down-regulate HIF-1α in a more potent and sustained manner compared to CPT-11.