Though such observations supported a potent genetic contribution, the limitations of a purely genetic approach to IBD, in general, and UC, in particular, were evident from early on.
Initial exploration identified aryl benzofuropyrimidinones that were potent, but had cell permeability limitation.
Paclitaxel (PTX) is a potent anticancer drug which suffers limitations of extremely low oral bioavailability due to low solubility, rapid metabolism and efflux by P-gp transporters.
HDP-mimicking peptidomimetics thus have been developed to mimic the structure and mode of action of HDPs, while circumventing the aforementioned limitations and displaying potent activity against multidrug-resistant bacteria.
Although our study is one of the first to evaluate sex differences in childhood response to potent combination ART, it has limitations.
The therapeutic limitations with earlier potent serotonergic agents such as D-fenfluramine were the nonselective effect on 5-HT receptors causing different side-effects including valvular heart disease.
Post-Leveson, the British press has a new, potent vitriol for anything it deems a limitation or restriction on its freedom.
Harrington, who faced Denver four times a year when he played for the Golden State Warriors, said the Nuggets' limitations were obvious, despite a potent lineup that featured Anthony, Camby, Kenyon Martin and J. R. Smith.
As with James, the result is both aesthetically and psychologically potent -- and weakened only, perhaps, by certain limitations that tell us more about the author than they do about his ostensible subject, which in this case is, in fact, the "pure coldness" that for Toibin was James's life.
