Thus, these findings suggest that the leaf extracts from M. oleifera had strong antiproliferation and potent induction of apoptosis.
A functional linkage between potent induction of the major CYP (1 3) genes and transcriptional down-regulation of MDR1 gene in drug-resistant tumor cells is hereby hypothesized.
More importantly, after treatment with DHA, A549GR cells showed more potent induction in Bax activation, loss of mitochondrial membrane potential (ΔΨm), caspase activation and apoptosis than A549 cells.
Used as a combination, such molecules should facilitate antigen presentation by professional APCs and lead to a potent induction of T cell-mediated effector and immune memory mechanisms.
RSI was defined as the administration of a potent induction agent followed immediately by a rapidly acting paralytic agent to induce unconsciousness and motor paralysis for intubation [1, 8, 15, 19, 21].
These observations could lead to a more informed selection and design of other HDACi with a more refined targeting profile, and prioritization of latency reversing agents of other classes to be used in combination with SAHA to achieve more potent induction of HIV expression.
Here we report that progesterone and various synthetic steroids with progestin potencies (norethisterone acetate, MPA, and Tibolone) counteract cell growth induced by hydrogen peroxide (H2O2), through a potent induction of catalase activities, in breast cancer cells and normal human epithelial breast cells.
The less potent induction by tunicamycin most likely results from absence of the targeted process, N-linked glycosylation, in proinsulin maturation.
We showed that TGFβ1 (4 ng/ml, 6 hours) caused potent induction of CCN2, collagen I and αSMA mRNAs in human dermal fibroblasts (Fig. 5A).
This reduction of T cell activity may result in a more potent induction of neutralizing antibody responses, clearing the viral infection.
Kim et al. [34] found a very potent induction of interferon α and β by short single-stranded RNAs (ssRNAs) transcribed with T3, T7 and Sp6 RNA polymerases.
