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A similar concentration-dependent effect of Boc5 to amplify insulin secretion was observed in rat insulinoma INS-1E cells co-incubated with 16 mM glucose for 30 min. Exendin-4 was equieffective, but 2800-fold more potent in the same assay (data not shown).
The study of the expression of COX-2 or mPGES-1 and the release of prostaglandins in activated chondrocytes showed that 15d-PGJ2 wastronglyly inhibitory, whereas the high-affinity PPARγ agonist rosiglitazone was marginally potent in the same concentration range.
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Ganciclovir (1), the standard of care for HCMV, is more than 400-fold less potent in these same assays.
That situation cannot occur when the GOIs present very different average transcript levels, or when a single GOI presents either potent repression or strong induction in the same study.
NSC23925 was 20-fold more potent than verapamil and 50-fold more potent than CsA in the same concentration.
The night was a powerhouse again, made only more potent a year later when, in the same season, NBC added both "Friends" and "ER" NBC remained largely untouchable on Thursdays the rest of the 1990's.
Great, freshly ground dried yellow ginger is supposed to be wonderfully potent and sweet smelling in the same way that licorice or star anise is, but I have never found it so.
The finding that physiologic MPA is both a potent progestin and androgen in the same cell type has important implications for women's health.
To a lesser but nevertheless potent extent, the same culture gets tried and executed by Neil Barofsky in his book, Bailout.
It was a theocracy, like Iran, slightly less potent but the same situation.
She is pure digitally, ethereal, and potent at the same time.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com